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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
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| Česky / Czech version | Trans. Hemat. dnes, 12, 2006, No. 2, p. 100–103. |
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Idiopathic thrombocytopenic purpura in pregnancy refractory to immunosuppressive
treatment – case report Procházková J.1, Procházka M.2, Papajík T.1, Látalová E.2, Hluší A.1, Ľubušký M.2, Neoral Č.3,Geierová M.4, Indrák K.1 1Hemato-onkologická klinika FN a LF UP Olomouc 2Porodnicko-gynekologická klinika FN a LF UP Olomouc3I. chirurgická klinika FN a LF UP Olomouc 4Ústav patologické anatomie FN a LF UP Olomouc |
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Summary: Idiopathic thrombocytopenic purpura (ITP) represents an autoimunne disorder complicated by isolated, variably
severe thrombocytopenia. The incidence of this condition in pregnancy is 1–2 cases / 1000 uncomplicated deliveries.
The main therapeutic approaches in pregnancy include corticosteroids, intravenous imunoglobulins (IVIG) and
splenectomy. We present a case of ITP in 27 year-old female during her second pregnancy. The illness was resistant
to therapy with corticosteroids (prednisolone 1 mg/kg) as well as to the combination treatment with cyclosporine A.
High doses of IVIG led to a few days response only. Due to this poor response we decided to perform splenectomy
at the beginning of the 3rd trimester. The surgery and subsequently childbirth of a healthy newborn passed uneventfully.
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