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  Česky / Czech version Čes. a slov. Neurol. Neurochir., 69/102, 2006, No. 3, p. 175–180.
 
How to Improve Multiple Sclerosis Treatment: Genetic and Pharmacogenetic Approaches 
Emmanuel Monnet1 and Filippo Martinelli Boneschi1,2 

1Serono Genetics Institute, Evry, France 2Department of Neurology, Scientific Institute San Raffaele, Milan, Italy
 


Summary:

       The availability of the human genome sequence combined with recent technological advances allows investigating the genetics of complex diseases and response to treatments with a whole new angle. While in the past, studies conducted to decipher the role of genetics was limited to very small portions of the genome, today, DNA chips give researchers the power to look at the entire genome with simple tests. These new tools help scientists to understand more deeply molecular mechanisms associated with drug responses and the development of diseases. This approach has been applied to better understand the genetic mechanism of multiple sclerosis, and new information is already available to potentially develop new treatments. These research opportunities should improve multiple sclerosis management and bring hope to patients.

        Key words: multiple sclerosis, pharmacogenetics, genetics
       

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