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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitř. Lék., 47, 2001, No. 12, p. 829-833 |
Our Experience with Intraarterial Locoregional Chemotherapy of Colorectal Carcinoma Metastatizing finto the Liver Kiss L1, Marková J.1, Tomášek J.1, Vyzula R 2'1, Válek V.3, Boudný J.3, Kala Z 4, Hanke L4, Ostřížek T 4, Leypold J.5 lOddělení klinické onkologie FN Brno, pracoviště Bohunice, přednosta prim. MUDr. Igor Kiss 2 HIinika komplexní onkologické péče, přednosta doc. MUDr. Rostislav Vyzula, CSc., MOÚ Brno, ředitel doc. MUDr. Jan Žalouchk, CSc. 3Radiologická klinika FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Karel Benda, 4Chirnrgická klinika FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Vomela, CSc. SII. chirurgická klinika FN u sv. Aniiy Brno, přednosta prof. MUDr. Jindřich Leypodl, CSc. |
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Summary: Locoregional chemotherapy is one of the possible ways of treatment of inoperable metastatic affection of the liver by colorectal carcinoma. The advantage of regional administration of the cytostatic is the possibility to achieve a higher local concentration of the cytostatic associated with a higher percentage of therapeutic responses. In our department we preferred combined locoregional intraarterial chemotherapy (5-fluorouracil /Mitmycin C/Doxorubicin) combined with systemic intravenous chemotherapy (5-fluorouracil/leukovirin). Locoregional cghemotherapy was administered in the majority as chemotherapy of series 2 or 3 with a very good tolerance. In 2/19 patients we observed marked diminution of liver metastases and subsequent operability and with a duration of complete response for 13 and 18 months. In 7/19 patients a partial therapeutic response was achieved. The total therapeutic response (complete and partial) was 47%. Locoregional chemotherapy attains a higher therapeutic response as compared with systemic chemotherapy and is associated with an acceptable toxicity.
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