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  Česky / Czech version Vnitř. Lék., 47, 2001, No. 1, p. 36-45
 
Clinical Manifestations of AL-amyloidosis and Some other Types of Amyloidosis 
Adam Z., Ščudla V. 

lInterní hematoonkologická klinika FN, Brno, pracoviště Bohunice, přednosta prof. MUDr. J. Vorlíček, CSc. III. interní klinika FN, Olomouc, přednosta prof. MUDr. V. Ščudla, CSc.
 


Summary:

       Amyloidosis is the term for specific pathological peptide deposits in various tissues. Amyloid substances may be the manifestation of the follwng nosological units: AL-amyloidosis, AA-amyloidosis, ATTR-amyloidosis, betaz-microglobulin amyloidosis and possibly othr familiar forms of amyloidosis. The most frequent symptoms of amyloidosis are: 1. proteinuria with nephrotic syndrome, 2. cardiac failure with restrictive cardiomyopathy, 3. unexplicable hepatomegaly, 4. idiopathic peripheral polyneuropathy, 5. haemorrhagic manifestations and symptoms of increased fragility of the capillaries while the number of thrombocytes is normal, 6. periorbital haematomas and 7. macroglossia. Diagnostic and therapeutic procedures differ according to the type of amyloidosis and are analyzed in detail in the text.

        Key words: Amyloidosis - Clinical manifestations - Diagnosis
       

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