Celiac Disease and Female Infertility
Machač Š.1, Kolek A.2, Dostál J.1, Procházka M.1, Oborná I.1, Březinová J. Svobodová M.1, Kudela M.1
1Centrum asistované reprodukce, Gynekologicko-porodnická klinika FN a LF UP, Olomouc, přednosta prof. MUDr.M. Kudela, CSc.2Gastroenterologická ambulance, Dětská klinika FN a LF UP, Olomouc, přednosta doc. MUDr. V.Mihál, CSc. |
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Summary:
Objective: To determine incidence of subclinical forms of celiac disease in women with decreased
fertility.
Design: Screening test.
Setting: Department of Gynecology and Obstetrics, University Hospital, Palacký University, Olomouc.
Methods: 137 patients with fertility problems were included to the study. There were divided into
two groups, patients with infertility and patients with repeated pregnancy loss. Screening test for
celiac disease, serum level of antibodies tissue transglutaminase (tTGA) were performed in all of
them. Positive test was confirmed by serological level of anti endomysium antibodies (EmA) and
final diagnosis of silent celiac disease was done by enterobiopsy.Results: Celiac disease was found in two infertile patients (1.67%). In one patient the silent form was
diagnosed by enterobiopsy. The second disease was latent form. In patients with repeated pregnancy
loss we did not observe positive screening test.
Conclusion: We confirmed higher incidence of celiac disease in women with impaired fertility.
Key words:
celiac disease, infertility, repeated pregnancy loss
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