The antibiotic treatment of reactive arthritis patients derived
from the National registry of rheumatic disorders
Dejmková H.1, Mareš Z.1, Johanedisová J.2, Vítek P.3, Galatíková D.4, PetrováS.5, Lád V.6, Bačkovská M.7
1Revmatologický ústav Praha, 2Revmatologická ambulance Děčín, 3Centrum rehabilitace Zlín, 4Nemocnice – revmatologická ambulance Bruntál, 5Revmatologická ambulance Znojmo, 6Fakultní nemocnice, Dětská klinika Plzeň, 7Revmatologická ambulance Nové Město na Moravě |
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Summary:
This paper is composed of two parts. The first part informs about literature data on the antibiotic
treatment of patients with reactive arthritis. The second part informs about the significance of the
antibiotic treatment of patients with reactive arthritis from the National registry of rheumatic
disorders. Objective: To evaluate the relationship between starting antibiotic treatment and longtermtreatment
of patients with reactive arthritis fromthe National registry of rheumatic disorders.
Methods: Patients entered into the registry between 1999 to 2001 were investigated after two years.
The response was obtained from forty patients (50%) of the original group. Patients were then
divided into two groups – the first one, in which patients were treated with antibiotics from the
beginning of the disease and the second group, without antibiotic treatment. Total therapy and type
(nonsteroidal antirheumatics, glucocorticoids, salazopyrine) were evaluated and the groups were
compared. Results: There were no significant differences between groups with respect to total
therapy – 41.2% of patients in the group with ATB and 56.5% in the group without ATB were still
treated after two years. Neither the treatment with nonsteroidal antirheumatic drugs (5.9% of
patients in the group with ATB and 17.4% in the group without ATB) nor with salazopyrine (29.4%
in the group with ATB and 34.8% in the group without ATB) reached the statistically significant
difference between groups. Statistically significant difference between groups were found in
patients treated with glucocorticoids (17.7% of patients in the group with ATB and 8.7% in the group
without ATB). However, because of the small numbers the interpretation of these findings must be
taken with caution. Conclusion: These results are in accordance with most of the literature data.
The antibiotic treatment has not significantly affected prognosis of patients with reactive arthritis
from the National registry.
Key words:
reactive arthritis, antibiotic study, National registry, rheumatic disorders
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