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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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Česky / Czech version | Vnitřní lékařství, 50, 2004, č. 9, s. 685 - 688 |
Pathophysiology and Classification of
Pulmonary Hypertension Sládková H., Jansa P., Susa Z., Aschermann M. II. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Michael Aschermann, DrSc., F.E.S.C. |
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Summary: Pulmonary hypertension is present when the mean pulmonary pressure is increased above 25 mm
Hg in a rest or above 30 mm Hg during exercise. It is possible to divide it from different point of
view. Well known is pathophysiologic classification and Venice classification suggested by WHO
symposium 2003. The rise of arterial pulmonary pressure is caused by three essential abnormalities,
these are elevated pulmonary vascular resistance, blood flow and pulmonary artery wedge
pressure. Vasoconstriction, remodeling of vessels and in situ trombosis are pathogenetic mechanism
which contribute to rise of pulmonary hypertension.
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