The objective of the clinical studywas the assessment of the effect of a combined treatment with thiocolchicoside and diclofenac in outpatients down with algic vertebrogenic lumboischialgic syndrome, and simultaneously to follow up safety of the treatment and the frequency of side-effects. A total of 1226 patients were entered into the study, who suffered the above-mentioned syndrome and met the required criteria. Each patient was examined by a physician at the beginning of the study and on its termination (overall duration of therapy 7 days). Each subjects assessed the degree of painfulness according to one’s own feelings, on termination of the study also the effectivity of therapy. Out of 1196 probands a positive effect of the therapy was observed in 1159 (96.9 %), 37 patients (3.1 %) noted no results of therapy. Only 72 patients (6 %) rated the tolerance of the drugs as „bad“, in all other 1180 cases (94 %) it was rated as „good“ to „very good“. No serious complication has been noted in the course of treatment, in 187 subjects there was found at least on side-effect for which therapy was interrupted in 38 of them. The study demonstrated a great effectivity of this combined therapy (thiocolchicoside and diclofenac) in outpatients suffering acute algic vertebrogenic syndrome and a good tolerance of the drugs.

        Key words: acute vertebrogenic lumboischalgic syndrome - therapy - thiocolchicoside - diclofenac.