Pharmacoeconomic Aspects in the Treatment of Depressive Disorders Rational prescribing of drugs may lead to balanced health insurance budget. This problem is the object of a relatively new brunch – pharmacoeconomics. This article follows some of the trends in the treatment of depressive disorders and intends to present that the treatment with so called expensive psychopharmacs does not necessarily have to mean higher global costs. On the contrary it may reduce them. This article compares direct and indirect expenses and shows that direct medical expenses are often only a little part of the global cost.

        Key words: health insurance, pharmacoeconomics, health costs, depressive disorder, health care.