![]() |
CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
Journals - Article | |
![]() |
![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Česky / Czech version | Vnitř. Lék., 49, 2003, No. 7, p. 535 - 540 |
Microvascular Reactivity
in Type 2 Diabetes and its Relationship to the System of IGF-I and its Binding Proteins Kršek M., Prázný M., Škrha J., Justová V., Lacinová Z., Haas T. III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc. |
|
Summary: Background and Aim: System of insulin-like growth factor-I (IGF-I) and its binding proteins
(IGFBP) may be involved in the pathogenesis of vascular damage in Type 2 diabetes. Aim of the
study was to analyse the relationship between this system and microvascular reactivity in Type 2
diabetes as measured by laser-Doppler flowmetry. Methods and Results: Thirteen Type 2 diabetic
patients (8 women and 5 men) with microangiopathy and fifteen healthy subjects (8 women and 7
men) were examined clinically, underwent laser-Doppler flowmetry and intima-media thickness
measurements. Fasting serum levels of IGF-I, IGFBP and lipids were examined. Percentage perfusion
increase in the test with postocclusive reactive hyperaemia (PORH) as well as in that with
thermal hyperaemia (TH) were significantly decreased in Type 2 diabetic patients (p < 0.05).
Maximal perfusion after heating (THmax) was lower in Type 2 diabetic patients. Reaction of
microcirculation after heating (THmax/t) was slower in Type 2 diabetic patients (p < 0.001). The
changes in microvascular reactivity didn’t significantly correlate with any of measured parameters
of IGF-I/IGFBP system. Conclusions: Microvascular reactivity is impaired in Type 2 diabetic
patients. The function of microcirculation is not significantly related to the particular parameters
of the IGF-I/IGFBP system.
|
|
Order this issue
|
BACK TO CONTENTS | ||
| HOME PAGE | CODE PAGE | CZECH VERSION | |
© 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ |
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o. |
WEBMASTER |