Apolipoproteins in Cherokee Children and
Adolescents
Blackett P. R.1, Wang W.2, Quintana E.3, Alaupovic P.4, Lee E. T.5
Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma1 Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma2 WW Hastings Indian Hospital, Tahlequah, Oklahoma3 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma4 Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma5 |
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Summary:
Since American Indians are susceptible to type 2 diabetes and associated cardiovascular risk,
we determined the prevalence of risk factors in relation to age so that the data might reveal early
predictors and intervention targets. We studied 5–20 year-old Cherokee Indians, who are members
of the largest Indian Nation in Oklahoma. When we studied those without diabetes, we found
that apolipoprotein B, apoC-III bound to apoB and the apoB:A-I ratio increased in proportion to
the fasting insulin resistance (HOMA-IR), whereas HDL-C, LpA-I and LpA-I:A-II decreased, particularly
in boys during adolescence. Visceral fat measured as the waist circumference had a significant
effect on the HDL lipoproteins and HDL-C. Lp(a) was lower than in other ethnic groups,
but when elevated, the levels may compound cardiovascular risk.
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