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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
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| Česky / Czech version | Čes a slov. Gastroent. a Hepatol, 2004, roč. 58, č. 4, s. 141-144. |
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Viral Hepatitis D – First Experience of its Treatment Husa P.1, Linhartová A.2, Němeček V.2, Husová L.3 1Klinika infekčních chorob, FN Brno, pracoviště Bohunice 2Národní referenční laboratoř pro virové hepatitidy Státního zdravotního ústavu Praha 3Interní gastroenterologická klinika, FN Brno, pracoviště Bohunice |
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Summary: Virus of hepatitis D is a unique animal satellite virus till now known who needs for its transfer and replication
the presence of hepatitis B virus. Infection by hepatitis D virus is in Czech Republic very uncommon. The
result of antiviral treatment in patiens suffering from hepatitis D is not satisfactory. Interferon alpha in
higher dosis (10 MU three times a week for 12 months) is recommended. The authors managed a female
patient from Ukraine for 52 weeks by interferon alpha. During treatment neither transient disappearing of
serum viral nucleic acid (HDV RNA) nor serum alaninaminotransferase activity normalization were mentioned.
Due to neutropenia a significant reduction of interferon dosage was introduced.
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