Antigen Ki-67 in Decisions on Indication of Cystectomy
in a Female Patient with Preservation of the
Urethra
Jarolím L.1, Bennett R.2, Kawaciuk I.1, Verner P.1, Campr V.3, Grim M.4, Naňka O.4, Hyršl L.1, Hanek P.1, Dušek P.1
1Urologická klinika, Univerzita Karlova 2. LF a FN Motol, Praha, přednosta doc. MUDr. I. Kawaciuk, CSc. 2Oddělení patologie, Nemocnice Rakovník, přednosta MUDr. R. Bennetová 3Ústav patologie a molekulární medicíny, Univerzita Karlova 2. lékařská fakulta a FN Motol, Praha, přednosta prof. MUDr. R. Kodet, CSc. 4Anatomický ústav, Univerzita Karlova, 1. lékařská fakulta a VFN, Praha, přednosta doc. MUDr.M. Grim, DrSc. |
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Summary:
The nuclear antigen Ki-67 is present in actively dividing
cells and it has been demonstrated that Ki-67 reactivity
correlates with conventional prognostic indicators in several
tumours. The monoclonal antibody MIB1 is used to
determine the antigen and the proportions of cells undergoing
active division.
The present study demonstrated, that in female patients
with urothelial bladder tumours and negative Ki-67 in
transurethral biopsy of the bladder neck (borderline
1,5%) a negative histological finding of the cranial edge
of the urethra. Ki-67 staining provides an easy method of
determining the proliferative urethral turnover that
might provide additional prognostic information. Further
studies are needed with a greater number of female
patients for an assessment of long-term results.
Key words:
bladder cancer, cystectomy in female, tumour
markers, Ki-67
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