Children Born after Intracytoplasmic Sperm Injection (ICSI):
Factors of Infertility, Pregnancy Complications, Neonatal Period
and Neonatal Characteristics
Šnajderová M.1,2, Mardešić T.2,3, Zemková D.1, Šípek A.4,5, Gregor V.2,6, Krejčířová D.2,7, Sobotková D.4, Kraus J.8, Lánská V.9
1Pediatrická klinika 2. LF UK a FN Motol, Praha, přednosta prof. MUDr. J. Lebl, CSc. 2Institut postgraduálního vzdělávání ve zdravotnictví, Praha, ředitel MUDr. A. Malina, Ph.D. 3Sanatorium Pronatal, Praha, vedoucí lékař doc. MUDr. T. Mardešić, CSc. 4Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc. 53. LF UK, Praha, děkan doc. MUDr. B. Svoboda, CSc 6Oddělení klinické genetiky, Fakultní Thomayerova nemocnice, Praha, ředitel MUDr. K. Filip, CSc., MBA 7Oddělení klinické psychologie, Fakultní Thymayerova nemocnice, Praha, ředitel MUDr. K. Filip, CSc., MBA 8Dětská neurologická klinika, 2. LF UK a FN Motol, Praha, přednosta doc. MUDr. V. Komárek, CSc. 9Oddělení statistiky, IKEM, Praha, ředitel doc. MUDr. J. Malý, CSc. |
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Summary:
Objective: To analyze the type of infertility, pregnancy and neonatal outcome in children conceived after
intracytoplasmic sperm injection (ICSI children).
Design: Prospective open cross-sectional clinical study.
Setting: University hospital and private IVF unit.
Methods: Type of infertility, pregnancy complications, neonatal period and neonatal characteristics were
evaluated in 135 newborns conceived after ICSI from singleton and twin pregnancies and compared to
general population.
Results: The percentage of twins was significantly higher after ICSI compared to general population
(31% versus 1.7%; p<0.001) as well as the percentage of caesarean section deliveries (31% versus 17.8%;
p<0.001). Some complication in neonatal period was found in 21.5% ICSI newborns (18 out of 42 twins
and 12 out of 93 singletons; p< 0.001). Some complication during the course of pregnancy was found in
50.9% ICSI children.
Conclusions: no differences in gestational age, birth weight and birth length were found when ICSI and
spontaneously conceined (sc) singletons and ICSI and SC twins were compared. However, complications
during the course of pregnancy and in the neonatal period were more frequent in ICSI conceived children.
Key words:
ICSI, type of infertility, pregnancy, neonatal period
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