Thyroid Peroxidase in Thyroid Gland Differential Diagnosis. The Marker of
Malignancy or Differentiation?
Kholová I.1, Ryška A.1, Ludvíková M.3, Čáp J.2
1Fingerlandův ústav patologie a 2II. interní klinika Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice, Hradec Králové 3Šiklův patologicko-anatomický ústav Lékařské fakulty Univerzity Karlovy, Plzeň |
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Summary:
Human thyroid peroxidase (hTPO) is a membrane protein with a key role in the thyroid hormones
synthesis. Loss of hTPO was described in malignant tumours of the thyroid gland. hTPO was
tested as a marker of malignancy. Immunohistochemical study of hTPO in 321 thyroid lesions (45
malignant tumours, 72 benign tumours, 199 benign non-tumours lesions, and 5 normal thyroid
glands) is presented. The sensitivity of hTPO in predicting malignancy in thyroid is 64 %, and the
specificity is 87 %. Thus, hTPO is of limited value in the diagnosis of thyroid malignancy. The
authors discuss the role of hTPO as a marker of differentiation.
Key words:
human thyroperoxidase - thyroid gland - tumours - marker of malignancy - marker of
differentiation - immunohistochemistry
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