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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Vnitř. Lék., 49, 2003, No. 7, p. 559 - 562 |
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A Contribution to Molecular Diagnosis of Pancreatic Cancer Dítě P.1, Lukáš Z.2, Hermanová M.2, Kroupová I.2, Kleibl Z.4, Brázdil J.2, I.2, Kleibl Z.4, Brázdil J.2, 1Interní gastroenterologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. P. Dítě, DrSc.2Patologicko-anatomický ústav Lékařské fakulty MU a FN Brno, pracoviště Bohunice,přednosta prof. MUDr. K. Dvořák, DrSc.3Onkologická klinika 1. lékařské fakulty UK a VFN, Praha, přednosta doc. MUDr. L. Petruželka, CSc. 4Ústav lékařské chemie a experimentální onkologie 1. lékařské fakulty UK a VFN, Praha, přednosta doc. MUDr. B. Matouš, CSc.5Chirurgické oddělení nemocnice Delta, Brno, přednosta prim. MUDr. Alexej Pátek |
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Summary: Present diagnostic possibilities virtually do not make it possible to diagnose early stages of
pancreatic cancer. Likewise, it is very difficult to differentiate between pancreatic cancer and
chronic pancreatitis. The methods of visualization are insufficiently sensitive and the determination
of certain genes could enrich our diagnostic opportunities. Considerable attention in this
direction has been devoted to the determination and evaluation of the presence of oncogene
K-ras. Our initial experience with the determination of K-ras in preparations from patients with
pancreatic cancer or with chronic pancreatitis confirmed that K-ras in an oncomarker associated
with adenocarcinoma of pancreas, whereas in patients with chronic pancreatitis it occurs in
about 10 % of the examined samples.
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