Aterosclerosis is a leading cause of morbidity and mortality in diabetics. Macrovascular diseases – myocardial infarction, cerebral vascular accident, ischemic lower extremities - start in persons with diabetes earlier and in a bigger scope then in non-diabetics. Development of these changes is determined by diabetic vasculopathy which is connected with endothelial dysfunction, hypercoagulation state, and platelet abnormalities. Treatment of a patient with diabetes is based on compensation of diabetes and management of hypertension and dyslipidaemia. Drugs that inhibit platelets constitute an important part of prevention of cardiovascular disabilities in diabetics.

        Key words: Diabetes mellitus - Aterosclerosis - Acetylsalicylic acid