In a retrospective study we evaluated morphine hydrochloride (Vendal retard) in premedication for spinal surgery or peripheral nerve surgery. 250 patients were enrolled. We also monitored its combination with other pharmacological agents – non-steroidal anti-inflammatory drug ketoprofen and benzodiazepines. We evaluated adverse effects of depot morphine formula, the need for atropine or naloxone administration, opioid dose during anesthesia, the effects of premedication and postoperative analgesia. Oral premedication with depot formula of morphine hydrochloride, 10 mg or 20 mg, in combination with non-steroidal anti-inflammatory drug ketoprofen, 100 mg, and benzodiazepine (especially oxazepam 10 mg) could be recommended not only in above mentioned, but also in other feasible indications.

        Key words: premedication – morphine hydrochloride retard – combination with NSAID – spinal and peripheral nerve surgery – postoperative analgesia