Objective: To present a review on the contemporary degree of the development of prophylactic HPV vaccines. Design: Review article. Setting: Department of Obstetrics and Gynaecology, 1st Medical Faculty and General Faculty Hospital, Charles University, Prague, Czech Republic. Methods: Literature review. Conclusion: The contemporary knowledge about relation of HPV infection and cervical cancer gives a theoretical presumption for the development of prophylactic HPV vaccines. Results of extended studies of quadrivalent and bivalent HPV vaccines justify to expect their soon introduction to clinical practice.

        Key words: prophylactic HPV vaccine, cervical cancer