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CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
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| Česky / Czech version | Vnitřní lékařství, 48, 2002, č. 10, s. 976 - 980 |
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Double Blind Randomized Multicentre Study of a Seven-day Eradication
Regime of Helicobacter Pylori by Omeprazole, Clarithromycin and Ornidazole vs.Omeprazole,
Clarithromycin and Metronidazole Dítě P.1, Kunovská M.1, Pulgretová D.2, Woznica V.3, Petrtýl J.4, Hůlek P.5, ..... 1Interní gastroenterologická klinika FN Brno, pracoviště Bohunice, přednosta prof. MUDr. P. Dítě, DrSc. 2Gastroenterologické oddělení ZÚNZ, Příbram, vedoucí MUDr. D. Pulgretová 3II. interní oddělení, Nemocnice Most, přednosta prim. MUDr. V. Vokráčka 4I. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof.MUDr. P. Klener, DrSc. 5I. interní klinika Lékařské fakulty UK a FN, Hradec Králové, přednosta doc. MUDr. M. Pleskot, CSc. |
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Summary: Effective eradication regimes of Helicobacter pylori infections are nowadays based on administration
of a substance with a strong suppressive effect on production of gastric HCl combined
with two antibiotics. As suppressor of gastric HCl production unequivocally some drug from the
group of proton pump blockers is used. As to antibiotics, in first line therapy the following are
recommended: clarithromycin, amoxicillin, metronidazole. A problem in the eradication therapy
of Helicobacter pylori infection in recent years is the increasing resistance to clarithromycin and
apparently also metronidazole. In the Czech Republic the resistance to clarithromycin in relation
to Helicobacter pylori is stabilized at a level lower than 3.0 %. Resistance to metronidazole was
reported in 1992 within the range of 24 % - 26 %, however in 2001 it was already 36.0 %. Therefore
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