Hereditary Predisposition for Development of Breast and Ovarian
Zikán M., 1Jančárková N., Pohlreich P., Matouš B. , Kleibl Z.,Stříbrná J., 1Živný J.
Ústav biochemie a experimentální onkologie 1. LF UK, Praha 1Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha
Part of breast and ovarian cancer cases develops on the hereditary predisposition, i.e. mutation in one of predisposing
genes. Although this proportion is relatively small, 5–10%of all breast and ovarian carcinomas, it represents a group
with clearly defined etiologic factor. Predictive analysis of unaffected family members allows to identify individuals
at high risk of cancer and to include them into the programme of primary and secondary cancer prevention. Following
article presents basic review of the hereditary predisposition to breast and ovarian cancer focusing especially on
BRCA1 and BRCA2 genes, which are responsible for almost three-quarters of those hereditary tumours.
breast cancer, ovarian cancer, BRCA1, BRCA2.