The presented experimental work is focused to examine effectivity of the amino acid 10% L-arginin.HCl mixture with antiglaucomatic - 2% Trusopt (carbonic anhydrase inhibitor) and with 0.5% Timoptol (non-selective
-blocker) and of the each single compound on intraocular pressure (IOP). In the group of 5 rabbits (New Zealander White) with physiological levels of IOP already the single amino acid L-arginin.HCl decreased the IOP (for 18.4% compared with 0.5%Timoptol and for 9.7% with 2% Trusopt). In case ofmixture with the mentioned antiglaucomatics the L-arginin.HCl significantly increases their activity. The showed results indicate the presence of the free amino acids and their interaction with the adequate antiglaucomatic is required for correct action. Based on this interaction a new bio-active metabolite is created (possibly called as „bio-antiglaucomatic“).

        Key words: the effect of antiglaucomatics on IOP in experiment, the effect of combination of the amino acid L-arginin.HCl mixture with the
-blocker and the carbonic anhydrase inhibitor on IOP