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  Česky / Czech version Čes. a Slov. Farm., 49, 2000, No. 4, p. 195-198
 
Evaluation of the Quality of Mexiletine Hydrochloride by Means of Capillary Electrophoresis 
PROKSA B., PROKSOVÁ A. 

Slovakofarma, a.s., Hlohovec
 


Summary:

       Mexiletine hydrochloride and its potential impurity xylenol were determined by micelar electrokinetic chromatography in a 25 cm long capillary. The effect of parameters – temperature, electric field, concentration of analyzed compounds, type and composition of background electrolyte – on the separation of analytes and precision of analysis was studied. The advantage of the elaborated method is a very short time of analysis (2.3 min) at the sufficient level of precision and reliability of results.

        Key words: mexiletine hydrochloride – xylenol – separation – determination – micelar electrokinetic chromatography.
       

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