Interventional Treatment of Multiple Vascular
Involvement in Young Male with Heterozygous
Familial Hypercholesterolemia
Lubanda J.-C. M., Šimek S., Linhart A., Aschermann M., 2Češka R.
2nd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, General Teaching Hospital, Prague, Czech Republic 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, General Teaching Hospital, Prague, Czech Republic |
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Souhrn:
We report a case of 31 year old man with heterozygous familial hypercholesterolemia and excessive tobacco use
leading to acute myocardial infarction as the first manifestation of premature atherosclerosis. The patvent was treated
by primary PTCA of occluded first marginal artery and at this time an attempt of recanalisation of occluded LAD
was unsuccessful. The patient was referred for mini coronary bypass graft of the LIMA to LAD. During evaluation
of carotid arteries we found a significant stenosis of the left internal carotid artery and occlusion of the left subclavian
artery which made the use of LIMA unsuitable. Therefore, another attempt of PTCA of the occluded LAD was
performed, this time with success. Hence PTA of the occluded subclavian artery was performed with good result.
The patient was treated with the standard therapy of CAD and combined lipid lowering agents with significant
reduction of plasma cholesterol. However, 2 years after the first MI, he suddenly died after swimming at the age of
31. In this patient the risk of premature CAD was increased by the presence of another powerful risk factor - the
excessive tobacco use. Acute physical exercise probably acted as a trigger of acute coronary events at the time of
both MI. Interventionalmethods were very effective in the treatment of multiple atherosclerotic lesions in this patient
and provided significant relief of symptoms. Treatment of heterozygous FH is briefly discussed in this article.
Klíčová slova:
heterozygous familial hypercholesterolemia, tobacco use, PTCA, PTA, statins, coronary artery diseases,
premature atherosclerosis, AMI.
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