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  Česky / Czech version Čas. Lék. čes., 142, 2003, No. 9, pp. 528–529.
 
Gene Therapy for Liver Tumours: First Clinical Trials 
Havlík R., Král V., 1Habib N. 

I. chirurgická klinika LF a FN, Olomouc 1Division of Surgery, Imperial College School of Medicine, Hammersmith Hospital, London
 


Summary:

       Only a small percentage of primary and secondary liver tumours is suitable for surgical resection. Gene therapy represents a novel strategy that seems to be effective both, in vitro and in vivo. The use of tumour suppressor gene p53 therapy, suicide gene therapy, immune gene therapy and therapy with replication-competent oncolytic adenoviruses in liver tumours already entered the first clinical trials. In patients with hepatocellular carcinoma, the first clinical trials in phase I and II showed good tolerance and low toxicity to gene therapy. However, the clinical benefit for the patients treated either with wild type p53 or E1B deleted adenoviruses were marginal.

        Key words: gene therapy, liver tumours, clinical trial.
       

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