The analgesic and antipyretic effect of the bark of willow has been known in Egypt and Greece for canturies. The
modern era of salicylates starts with a letter sent 1758 by Reverend Edward Stone to The Royal Society in London.
He described „an account of the success of the bark of willow in the cure of agues“. His report. erroneously attributed
to Edmond Stone. was published five years later. The active ingredient of willow bark. „salicine“. was first isolated
1828 by Joseph Buchner, then by Henri Leroux, and also prepared from the oil of wintergreen (Gaultheria) and
meadowsweet (Spirea ulmaria) by J. W. Lowig 1833. and called „Spirsäure“, which was already pure acetylsalicylic
acid. It was also synthetised 1853 by Ch. Gerhardt and finally 1897 in Bayer’s laboratoires by Felix Hoffman, who
also demonstrated its antiihflamatory efficacy. After two years of clinical trials with low doses, Bayer’s management
decided to start the productions and launched Aspirin as an analgetic worldwide in summer 1899. The first ASPIRIN
ERA bagun. A completely new epoch started when J. N. Vane and Priscilla Piner demonstrated 1971 that the main
mechanism of action of aspirin-like drugs is the inhibition of prostaglandin synthesis. In later studies the potency to
inhibit platelet aggregation with small doses of aspirin (30–125 mg) was demonstrated. The Physicians’Health Study
1988 confirmed this effect: aspirin significantly reduced the risk of both. fatal and non–fatal myocardial infarction.
and is now used in primary and secondary prevention of atherosclerosis. However the idea was not new: The use of
salicylates and aspirin was throughly discussed more than 50 years ago: Paul C. Gibson published 1949 a welldocumented
case report on efficacy of aspirin in patients with angina, and Kl. Weber and P. Klein in Prague used
Gibson’s mixture successfully for patients with acute myocardial infarction (1951). Recently, the efficacy and
security, the interactions and side–effects of low–dose aspirin have been studied and discussed. In chronic treatment,
any combination of two specific platelet antiaggregants should be avoided.
salicylates, aspirin, acute myocardial infarction, antiaggregants.