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  Česky / Czech version Čes. a Slov. Farm., 51, 2002, No. 1, p. 17-25
 
Drug Chirality 
ŘIČICOVÁ V., ROUSOVÁ Z., BENEŠ L. 

Ústav chemických léčiv Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno
 


Summary:

       Chirality is a stereochemical phenomenon in the area of drugs, influencing pharmacodynamic, pharmacokinetic, and biotransformation processes. On an example of known drugs, the present paper describes the relations of chirality to drog efflcacy, safety, toxicity, manifestations of drog interactions, and some other factors with a feedback action on the chirality-drog relationship.

        Key words: chirality - pharmacodynamics - pharmacokinetics - biotransformation
       

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