Relation Between Serum Levels of Leptin, Blood Cell Count, and
Erythropoietin Level in Hemodialiseds Patients
Haluzík M.,Marková M.,Sulková S.,Haluzíková D., Svobodová J.,
III. interní klinika 1. LF UK a VFN, Praha 1 Ústav hematologie a krevní transfúze, Praha 2 Interní oddělení Strahov 1. LF UK a VFN, Praha 3 Ústav tělovýchovného lékařství 1. LF UK a VFN, Praha |
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Abstract:
Background. Serum leptin levels are significantly increased in hemodialysed patients compared to healthy
subjects. There are some data suggesting the possible relationship of leptin and the regulation of haematopoiesis.
The aim of our study was to compare serum leptin levels in two groups of hemodialysed patients: the group treated
by recombinant human erythropoietin (n=40) (HD+EPO), the group without erythropoietin treatment (HD) and the
control group of healthy subjects (n=20) to explore the influence of erythropoietin treatment on serum leptin levels.
Methods and Results. The tendency towards lower body fat content and higher serum leptin levels was found in
both groups of HD patients compared to control group, but the differences did not reach statistical significance due
to high variability of those parameters (leptinu levels: HD 19.5±18.5, HD+EPO 24.9±23.3, K 10.4±8.8 ng.ml
-1
). The
erythrocyte count and haemoglobin levels in both groups of HD patients were significantly lower than in control
group. The erythrocyte count and haemoglobin levels were significantly lower in HD patients treated by erythro-
poietin compared to untreated HD group. The leptin/body fat content ratio was significantly higher in HD patients
compared to healthy subjects (HD 0.86±0,72, HD+EPO 0.92±0.78, K 0.35±0.21, p<0.05). Serum leptin levels in
all studied groups correlated positively with body fat content and negatively with erythrocyte count. No significant
relationships of serum leptin levels to erythropoietin levels or other parameters studied were found in any of groups.
Conclusions. Our study further supported the fact that serum leptin levels in HD patients are relatively higher
than in healthy subjects. Serum leptin levels in HD patients treated by recombinant human erythropoietin did not
significantly differ from HD patients without this treatment. Except of the negative correlation between serum leptin
levels and the erythrocyte count no statistically significant relationships of serum leptin levels and the blood count
parameters were found.
Key words:
leptin, hemodialysed patients, haematopoiesis, erythropoietin.
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