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  Česky / Czech version Čas. Lék. čes., 140, 2001, No. 22, p. 685-687
 
New Approach to Cholesterol 
Bzdúch V., 1Behúlová D., 2Kajaba I. 

I. detská klinika Detskej fakultnej nemocnice, Bratislava, SR IOddelenie klinickej biochémie Detskej fakultnej nemocnice, Bratislava, SR 2Ústav preventívnej a klinickej medicíny, Bratislava, SR
 


Summary:

       Although much is known about hypercholesterolemia and the associated risk for the development of atherosclerosis, vety little research has focused on altered cholesterol biosynthesis. Recent discovery tkat the biochemical basis for the human malformation syndrome, Smith-Lemli-Opiu syndrome appears to lie in altered cholesterol biosynthesis has changed this situation. Cholesterol has an extraordinary important functions in organism. Recommendations to lower serum cholesterol are widespread, yet low serum cholesterol is associated with poorly understood morbidity. Cholesterol is still an enigmatic, essential metabolite and much remains to learn about it.

        Key words: cholesterol biosynthesis, Smith-Lemli-Opiu syndrome, essential function of cholesterol, atherosclerosis, morphogenesis.
       

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