Background. Meta-analyses of epidemiological studies proved that hypertriacylglycerolemia (HTAG) is an
independent CHD risk factor. The VLDL lipoproteins, which are the main TAG carrier, are precursors of atherogenic
LDL and their increased concentration is related to the decrease of antiatherogenic HDL, increased ratio of small,
dense LDL and represents one of the causes of the endothelial dysfunction. According to some authors, HTAG is
one of the factors of the oxidation stress.
Material and Methods. 45 patients of the studied group received 200 mg of micronised fenofibrate per day for
six weeks. Before the beginning and after the end of treatment, following examinations were carried out: concentration
of plasma lipids, lipoproteins, and apolipoproteins, composition of fatty acids (FA) in main lipid plasma classes and
LDL (phosphatidylcholine – PC, TAG, cholesteryl esters – CE) and lipoperoxidation in VLDL and LDL, isolated
by preparative ultracentrifugation.
Results and Conclusions. In plasma, the treatment of HTAG led to a significant decrease of TC, TAG and apo-B
concentration and to the increase of cholesterol concentration in HDL and in both HDL 2 and HDL 3 subfractions. In
isolated LDL particles we observed a decrease of the TAG portion (by 25 %) together with significant lag phase
prolongation (by 33 %, P<0.05) and peak time retardation (by 24 %, P<0.05). In VLDL particles the concentration
of cholesterol became smaller (by 28%), TAG (by 26%), phospholipids (by 28%) (in all groups P<0.005) and the
lag phase became significantly longer (by 16%, P<0.01). Treatment with fenofibrate significantly reduced the linoleic
acid (18:2n-6) in PC and TAG plasma, CE and TG LDL, in a higher ratio of palmitoleic acid (16:1n-7) in CE LDL,
oleic (18:1n-9) in PC LDL, in significant concentration of total monoenic FA in PC and CE LDL and to a significant
increase of the concentration of myristic acid (14:0) in CE and myristic and stearic acids (18:0) in TAG LDL. From
our results it is possible to conclude that the six-week long treatment of HTAG with micronised phenofibrate led to
significant modification of LDL and VLDL composition accompanied by their lower lipoperoxidation indexes. These
favourable changes in oxidability were accompanied with changes in the composition of FA in CE, TAG and PC
plasma as well as LDL.
HTAG, VLDL and LDL composition, VLDL and LDL lipoperoxidation, composition of fatty acids,