Rheumatoid Arthritis –First Charac-
teristic of the Group of Patients of the National Register of the Rheumatic Diseases
Šedová L.1 ,Macháček S.1 ,Johanidesová J.2 ,Vítová J.3 ,Vlasáková V.3 , Záhora R.4 ,Pavelka K.1 ,Kyloušková M.5 ,Zvárová J.5
1 Revmatologický ústav,Praha,2 Revmatologická ambulance,Děčín,3 Interní odd.krajské nemocnice, České Budějovice,4 Revmatologická ambulance,Terezín,5 EuroMISE,Centrum UK a AV ČR |
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Summary:
Objective .Analyze demographic data and basic clinical and laboratoryx parameters of a group of
549 patients with rheumatoid arthritis assembled within the framework of the National register of
rheumatological diseases.Patients and methods .The investigation comprises patients who meet the
criteria of the American College of Rheumatology for rheumatoid arthritis with emphasis on the
early stage of the disease.X-ray pictures were taken,the clinical condition was evaluated according
to the articular index DAS,visual analogue scale of pain and the general condition,anamnestic and
clinical data were assessed by means of a questionnaire.For evaluation of the functional capacity
the HAQquestionnaire was used.For statistical processing of data Wilcoxon ’s double selection order
test,Pearson ’s χ 2 test,Fisher ’s exact test and McNemara ’s symmetry test were used.Results .Asto
diagnostic criteria of rheumatoid arthritis the clinical criteria are most frequent.Between groups
of patients who developed the disease in middle or advanced age no difference was found in clinical
parameters of the development of the disease.From the aspect of activity of the disease there is no
difference between groups with a positive rheumatoid factor and positivity of antinuclear antibo-
dies when compared with groups where with negativy of these parameters.The incidence of
subluxation of the cervical spine,the most serious skeletal manifestation of the disease was recorded
in 17.2 %of the investigated group.Pharmacotherapeutic data confirm a shift towards modernforms
of treatment.Conclusion .The data indicate that rheumatoid arthritis is a disease predominantly of
middle age.They do not confirm the presence of clinical subsets of the disease which depend on age
and positivity of rheumatoid factors.The ratio of affections of the cervical spine in patients is
significant and deserves to become the object of screening in out-patient practice.
Key words:
rheumatoid arthritis,demographic data,epidemiological investigations,treatment of
rheumatoid arthritis
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