Summary:
Antiphospholipid syndrome is a rate systemic autoimmune disease characterized by widespread arterial and venous
thrombosis, recurrent abortion and thrombocytopenia. Laboratory tests reveal antibodies against phospholipids.
These antibodies are detected by functional tests for the lupus anticoagulant, the anticardiolipin ELISA, the
anti-b2-glycoprotein 1 ELISA and ELISA tests for antibodies against other cofactors and phospholipids. Pathogenetic
mechanisms of thrombosis are poorly understood. Diagnostic assays for detection of antiphospholipid have not been
yet adequately standardized.
Key words:
antiphospholipid syndrome, antiphospholipid antibodies, lupus anticoagulant, laboratory detection.
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