Carbonyl Stress and Chronic Renal Failure
Kalousová M.,Zima T., Tesař V.,Štípek S.
Ústav lékařské chemie a biochemie 1. LF UK, Praha Ústav klinické biochemie 1. LF UK a VFN, Praha I. interní klinika 1. LF UK a VFN, Praha |
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Summary:
Pathogenesis of many diseases and their complications is linked to oxidative stress. In the last two years, the
attention has been paid also to carbonyl stress which is alosely related to oxidative stress. Carbonyl stress is
characterized as an increase of reactive carbonyl compounds caused by their increased formation and/or decreased
breakdown and excretion. Reactive carbonyl compounds can be formed from carbohydrates, lipids and amino acids
both by oxidative and non-oxidative pathways, can be detoxified by several enzymes and excreated by kidneys
depending on their function. Carbonyl compounds can form advanced glycation end-products (AGEs) and advanced
lipoperoxidation end-products (ALEs), which are known to take part in the pathogenesis mainly of diabetic and
uremic complications.
Key words:
oxidative stress, carbonyl stress, AGEs – advanced glycation end products, ALEs – advanced
lipoperoxidation end products.
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