Summary:
Many controversial studies concerning relation between angiotensin converting enzyme polymorphism and renal
and cardiovascular disease have been published during the last years. Most of the papers have suggested that the DD
genotype plays an important negative role in the progression of some renal diseases (e.g. IgA nephropathy, diabetic
nepropathy). The D allele may be an independent risk factor for development of the target organ damage in essential
hypertension. The therapeutic response on inhibitors of angiotensin converting enzyme depends on insertion-deletion
polymorphism. It probably also depends on the gender. The pathological mechanisms of insertion-deletion polymor-
phism have not yet been clearly identified.
Key words:
angiotensin-converting enzyme, insertion-deletion polymorphism, kidney, hypertension.
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