CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ | |
Journals - Article | |
Česky / Czech version | Čas. Lék. čes., 141, 2002, No. 24, p. 765–768. |
Kidney, Aging and Transplantation
Viklický O., Böhmová R., 1Heemann U. W. Klinika nefrologie a Oddělení klinické imunologie Transplantačního centra IKEM, Praha 1Universitätsklinikum, Essen, SRN |
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Summary: The discrepancy between the increasing number of patients listed for kidney transplantation and limited cadaver
donor sources has led the transplant community towards indication of elderly people as potential kidney donors.
Based on clinical data, the kidney grafts explanted from aged donors have limited survival rates compared with
younger ones. The donor age has been also implicated as the important alloantigen-independent risk factor for later
onset of chronic allograft neprohopathy called chronic rejection. In this review we focused on some pathophysiological
aspects of kidney aging and on the fate of transplanted kidney removed from elderly donors.
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